Dana-Farber Builds a Search Engine for Drugs That Destroy Proteins Instead of Blocking Them

Researchers discover smart molecular glue that activates inside oxidative cancer cells

Investigators at Dana-Farber Cancer Institute have developed a platform for systematically discovering molecular glues that could become protein degradation drug candidates.

Dana-Farber Builds a Search Engine for Drugs That Destroy Proteins Instead of Blocking Them

Dana-Farber researchers built a platform to systematically discover molecular glue degraders. How protein degradation differs from inhibition, and how early this is.

Novel Molecular Glue Discovery Platform Unlocks Undruggable Cancer Targets

Targeted protein degradation is a therapeutic strategy that leverages the ubiquitin–proteasome system to eliminate disease-associated proteins—including those that have traditionally been considered undruggable. Protein degraders remove unwanted proteins from inside a cell by disposing of them using the cell’s built-in recycling system. Specifically, a molecular glue degrader binds an E3 ligase and redirects it to tag a disease-related protein f…

Dana-Farber team develops degrader platform, discovers first metabolically

Dana-Farber Cancer Institute researchers have developed a systematic platform for discovering molecular glue degraders, a class of drug-like compounds that can redirect the cell’s own protein-disposal machinery toward disease-associated proteins. The approach could substantially broaden the number of proteins that can be eliminated therapeutically, potentially opening new strategies for treating cancer and other diseases. The […]

Systematic Platform Accelerates Identification of Novel Protein Degradation Drug Candidates

Investigators at Dana-Farber Cancer Institute have developed a platform for systematically discovering molecular glues that could become protein degradation drug candidates.