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Curcumin amorphous solid dispersions formed by Eudragit EPO and hydroxypropyl methylcellulose E50 achieve superior analgesic effect
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Curcumin amorphous solid dispersions formed by Eudragit EPO and hydroxypropyl methylcellulose E50 achieve superior analgesic effect
Abstract Poor solubility of curcumin (Cur) has greatly limited its applications. To establish Cur amorphous solid dispersions (Cur ASDs) with superior analgesic effect, Eudragit EPO (EuD) and hydroxypropyl methylcellulose E50 (HPMC E50) were combined applied. Crystallization inhibition function of HPMC E50 in Cur ASDs was studied by analyzing the viscosity change and glass transition temperature (Tg). Critical micelle concentration and molar sol…
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