US EditionTest Can Detect Crohn’s Disease Years Before Symptoms Show
The test detects an immune response to bacterial protein flagellin in genetically at-risk relatives, identifying over one third of future Crohn’s cases before symptoms appear.
- Sinai Health researchers identified a blood test that signals Crohn’s disease risk years before symptoms appear, reporting their findings in Clinical Gastroenterology and Hepatology.
- Because diagnosis often follows intestinal damage, the GEM Project tracks more than 5,000 healthy first-degree relatives to study Crohn’s onset.
- The test measures serum IgG response to flagellin, including Lachnospiraceae flagellin, with 28 individuals showing elevated antibodies and siblings having the strongest inflammation signals.
- If confirmed, the test could enable earlier diagnosis and possible prevention to reduce intestinal damage, but researchers caution antibodies appeared only in a subset and validation and mechanistic studies are underway.
- The GEM Project’s tracking of more than 5,000 first-degree relatives positions the research to influence screening strategies as IBD rates rise, and future validation studies are planned.
27 Articles
27 Articles
New research shows that the immune response to a protein from intestinal bacteria may act as an early indicator of the disease, paving the way for early diagnosis and prevention
Discovery carried out by Canadian institute early diagnosis by means of blood tests that measure the immune response of antibodies. Study aims at the development of preventive vaccines.
ABC FOX Montana
Test can detect Crohn’s disease years before symptoms show
The discovery opens the door to early diagnosis and potential prevention of the chronic form of inflammatory bowel disease.
Crohn’s Disease May Be Detectable Years Before Symptoms
A blood test may detect Crohn’s disease years before it strikes—changing how the condition is predicted and prevented. Researchers at Sinai Health have identified a blood test that can signal the risk of Crohn’s disease years before symptoms begin. The discovery raises the possibility of earlier diagnosis and, eventually, prevention for a condition that is [...]
Crohn's disease is a chronic inflammatory condition of the gastrointestinal tract that causes persistent symptoms, pain, and fatigue, significantly affecting quality of life.
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