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Chargers’ Makeshift Offensive Line Faces Bigger Challenge Against Colts

Chargers aim to keep their AFC West lead as Khalil Mack returns from injury against Colts, who lead the AFC South and seek revenge for their only loss this season.

  • On October 16, 2025, the Los Angeles Chargers host the Indianapolis Colts at SoFi Stadium on Sunday, with the Chargers leading the AFC West and the Colts topping the AFC South.
  • Harbaugh, who quarterbacked the Colts in the 1990s, said his finest season was 1995, describing it as `dipped in magic waters` when playing for Indianapolis.
  • Khalil Mack said he wants to play after sitting out four games, adding he's `slightly ready to go` since his activation window opened Tuesday, but GM Joe Hortiz and coach Jim Harbaugh will decide.
  • Chargers defensive needs center on Mack's return against a high-powered Colts offense, and the game could affect playoff seeding in January.
  • Injury updates show multiple Chargers limited or sidelined while Quentin Johnston, Chargers wide receiver, is cleared to play after missing last week. Joe Alt, Chargers left tackle, is listed as doubtful for Sunday after practicing Thursday and Friday.
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Associated Press News broke the news in United States on Thursday, October 16, 2025.
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