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Christina Applegate reveals she was misdiagnosed with MS

Doctors say new testing showed Applegate never had multiple sclerosis, but she still has debilitating symptoms and will undergo further investigation.

  • On Tuesday, actress Christina Applegate revealed on her podcast MeSsy that she was misdiagnosed with multiple sclerosis in 2021. The 54-year-old tearfully shared that new medical technology led to this discovery after years of believing she had the autoimmune disease.
  • Applegate, who first announced her diagnosis in 2021, had become a public advocate for the condition alongside her co-host, The Sopranos actor Jamie-Lynn Sigler. Sigler was diagnosed with multiple sclerosis roughly 25 years ago.
  • Returning to the podcast after seven months away, Applegate expressed frustration that she still experiences debilitating symptoms. "This may come as great news, but to me, I'm back at square one," she said, describing the lack of clarity as "unnerving."
  • Her medical team is now working to determine the underlying cause of her condition. Although she does not have multiple sclerosis, Applegate continues to rely on a wheelchair, with many illnesses capable of mirroring her symptoms.
  • Best known for roles in Married with Children and Dead to Me, the Emmy-nominated actor retired from acting in 2022 due to her health. She previously overcame a breast cancer diagnosis in 2008 and received a standing ovation at the 2024 Emmy Awards.
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+22 Reposted by 22 other sources
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Christina Applegate says she was misdiagnosed with MS. What her doctor told her

Christina Applegate says that she was misdiagnosed with multiple sclerosis after years of debilitating symptoms – and that she's "back to square one" with her health journey.

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<p>The star of the cult series Applegate admitted that she was wrongly diagnosed with a difficult doctor told the actress that she did not have multiple sclerosis. Despite this, Applegate still has severe symptoms and is looking for their cause.</p>

·Kyiv, Ukraine
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+3 Reposted by 3 other sources
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Christina Applegate reveals she was misdiagnosed with MS

Christina Applegate has revealed she was misdiagnosed with multiple sclerosis (MS) and feels like she is "back at square one".

·Ireland
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TMZ broke the news in Burbank, United States on Tuesday, October 20, 2026.
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