Cholesterol-craving cancers need lipid enzymes to use metabolites for growth, study shows
Blocking PI5P4K enzymes creates a cholesterol traffic jam in TP53-mutant cancer cells and suppresses tumor growth in mice and human cell models.
2 Articles
2 Articles
Cholesterol-craving cancers need lipid enzymes to use metabolites for growth, study shows
While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite. Some tumor cells use as much cholesterol as they can access to accelerate their growth beyond the capabilities of normal cells.
Enzymes Involved in Cholesterol Transport May Point to New Cancer Therapies
Some types of cancer have a relentless appetite for the metabolite cholesterol, using as much as they can access to accelerate their growth beyond the capabilities of normal cells. Research by scientists at Sanford Burnham Prebys Medical Discovery Institute and collaborators at the University of Illinois Chicago have now unveiled a potential method for turning the table on these tumors by subverting their cholesterol cravings. The researchers’ s…
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