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Cholesterol-craving cancers need lipid enzymes to use metabolites for growth, study shows

Blocking PI5P4K enzymes creates a cholesterol traffic jam in TP53-mutant cancer cells and suppresses tumor growth in mice and human cell models.

Summary by Medical Xpress
While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite. Some tumor cells use as much cholesterol as they can access to accelerate their growth beyond the capabilities of normal cells.

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Medical Xpress broke the news on Friday, May 22, 2026.
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