US EditionChinese Surgeons Achieve World’s First Transplant of Genetically Modified Pig Lung Into Brain-Dead Man
Chinese researchers transplanted a genetically modified pig lung into a brain-dead patient; the organ functioned for nine days without immediate rejection, advancing xenotransplantation research.
- On Aug. 25, researchers at the First Affiliated Hospital of Guangzhou Medical University transplanted a genetically modified pig left lung into a 39-year-old brain-dead male in Guangzhou, and the lung remained functional for nine days.
- Faced with a severe donor shortfall, World Health Organisation notes only 10% of global transplant needs are met, while xenotransplantation has grown, with pig hearts, kidneys and livers transplanted into humans.
- To reduce rejection, the donor pig with six genomic edits including GGTA1, CMAH, B4GalNT2 knockouts and human transgenes CD46, CD55, thrombomodulin showed oedema at 24 hours, antibody-mediated rejection on POD 3 and 6, ending the experiment on POD 9.
- Researchers urged larger preclinical and brain-dead human studies before trials in living patients can begin, cautioning that pig lung use in living patients remains a distant goal.
- Experts like Beatriz Dominguez-Gil noted lungs' unique challenges due to high blood flow and air exposure, requiring genetic engineering, preservation, and immunomodulation advances.
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Pig Lung Transplanted Into Man for 9 Days in Groundbreaking Study
Key Takeaways
·Calhoun, United States
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Chinese Scientists Transplanted A Pig Lung Into A Living Brain-Dead Human In First-Of-Its-Kind Experiment
pig-smiling In a medical first, Chinese scientists successfully transplanted a lung from a genetically modified pig into a living brain-dead human. The lung survived for nine days and provided hope for the future of pig-to-human transplantation, or xenotransplantation. The experiment, which involved a 39-year-old male who had been declared brain-dead prior to the procedure, occurred in Guangzhou, China, and the results were reported in the journ…
Surgeons in China have for the first time implanted a pig lung into a patient. The organ worked for nine days, but not without complications.
·Netherlands
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Coverage Details
Total News Sources61
Leaning Left14Leaning Right5Center17Last UpdatedBias Distribution47% Center
Bias Distribution
- 47% of the sources are Center
47% Center
L 39%
C 47%
14%
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