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Cardinals Hoping to Start Season with 2-0 Record, but Panthers Have Proved to Be Tough Opponent

The Panthers aim to rebound from a 26-10 loss and recent defensive struggles, facing a Cardinals team fresh off a 20-13 win with key players returning.

  • On Sunday, the Arizona Cardinals host the Carolina Panthers at State Farm Stadium, Glendale, Ariz., with kickoff at 4:05 p.m. and the BetMGM line favoring the Cardinals by 6 1/2; the Panthers seek revenge after a 36-30 overtime loss on Dec. 22, 2024.
  • Over the series since 2015, the Carolina Panthers have won seven of the past eight meetings, but last week they lost 26-10 while the Arizona Cardinals beat the Saints 20-13.
  • Ickey Ekwonu's likely return provides all five regular starters for Carolina, but Turk Wharton will miss 2-4 weeks and run defense remains a concern after allowing 143 yards to Travis Etienne in seven straight games.
  • With immediate stakes high, Bryce Young, Panthers quarterback, needs a bounce-back after three turnovers and completing 18 of 34 passes for 154 yards, while the turnover differential favors Arizona amid their strong home form.
  • Rookies and skill players to watch include Tetairoa McMillan, Panthers rookie wide receiver returning to Arizona, and RB Chuba Hubbard, who rushed for more than 1,100 yards in 2024 and will be a focal point Sunday.
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Cardinals hoping to start season with 2-0 record, but Panthers have proved to be tough opponent

The Carolina Panthers travel to face the Arizona Cardinals in Week 2 on Sunday. The Panthers have dominated the series in recent years, winning seven of the past eight since 2015.

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PHNX broke the news in on Thursday, September 11, 2025.
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