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Insulin Cream Offers Needle-Free Option for Diabetes

A polymer-insulin conjugate applied like a cream normalized blood glucose in diabetic animals as fast as injections with effects lasting 12 hours, researchers report in Nature.

Summary by Nature
Nature, Published online: 19 November 2025; doi:10.1038/d41586-025-03803-0Skin-permeable polymer shows promise at insulin delivery in animal experiments — plus, how the brain responds to unfamiliar languages.

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Chinese researchers have solved a seemingly impossible task: they have succeeded in delivering insulin into the body through the skin.

·Hungary
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A material that slides through the skin could one day make possible needleless insulin for people with diabetes. In mice and mini-porcs, binding of the penetrating polymer to insulin and application of the resulting compound as a cream have normalized blood glucose almost as quickly as insulin injection, report [...]

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Nature broke the news in United Kingdom on Wednesday, November 19, 2025.
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