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Boehringer Ingelheim Showcases Bold Vision for the Future of Cancer Care at ASCO 2025
Boehringer Ingelheim will present new data on the investigational therapies obrixtamig and zongertinib at the 2025 ASCO Annual Meeting in Chicago, IL.
This follows their multi-pronged strategy to tackle difficult-to-treat cancers by targeting key drivers HER2 and DLL3 due to limited options and poor outcomes.
Phase I data showed obrixtamig achieved a 40% objective response rate and 7.9 months median duration of response in 60 patients with high DLL3-expressing extrapulmonary neuroendocrine carcinomas.
Zongertinib, an oral HER2-targeted tyrosine kinase inhibitor, led to a notable increase in patients' physical capabilities—measured by activities such as walking and daily task performance—after 15 weeks of treatment in individuals with previously treated HER2-mutant advanced NSCLC, indicating meaningful improvements reported by patients.
These findings underscore Boehringer Ingelheim’s broad oncology pipeline and support potential advances for cancers with high unmet medical need.