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Blood work may tell us a person’s likelihood of developing colorectal cancer: Study
On Wednesday, an Epic Research analysis reported that adults younger than 45 with low liver enzyme levels—AST and ALT below 14 units per liter—showed a 65% and 68% higher likelihood of early-onset colorectal cancer diagnosis, respectively.
Colorectal cancer has become the leading cause of cancer deaths among people under 50 in the United States, prompting researchers to investigate metabolic and nutritional markers as potential explanations for rising case numbers.
Analyzing health data from more than 11,000 people in the United States aged 18 to 44, researchers found that low AST levels correlated with 65% higher likelihood of diagnosis, while low ALT levels showed 68% higher likelihood.
Dr. Daniel Sussman, leader of gastroenterology at University of Miami Health System's Sylvester Comprehensive Cancer Center, cautioned that these enzyme levels are generally regarded as normal and should not alter existing screening recommendations for younger adults.
Caleb Cox, head of research at Epic, stated "the appropriate response is further investigation" to determine how findings generalize to broader populations, as the study does not establish low enzyme levels as definitive risk factors.