Axonal Injury Is a Targetable Driver of Glioblastoma Progression

Blocking brain damage may slow glioblastoma growth

Blocking brain damage triggered by a glioblastoma, an aggressive brain cancer, may slow the growth of the cancer and allow the brain to keep working better for longer, according to a new study led by UCL (University College London) researchers.

Axonal injury is a targetable driver of glioblastoma progression

Glioblastoma (GBM) is an aggressive and highly therapy-resistant brain tumour1,2. Although advanced disease has been intensely investigated, the mechanisms that underpin the earlier, likely more tractable, stages of GBM development remain poorly understood. Here we identify axonal injury as a key driver of GBM progression, which we find is induced in white matter by early tumour cells preferentially expanding in this region. Mechanistically, axo…

Blocking Brain Damage Could Slow Brain Cancer Growth

A groundbreaking study conducted by researchers at University College London has unveiled a novel pathway to potentially slow down the progression of glioblastoma, the most aggressive and fatal form of brain cancer. By targeting the brain’s response to nerve cell injury caused by tumor growth, scientists discovered that the normally protective process of axon degeneration […]

Glioblastoma Progression Slowed by Blocking Axon Degeneration

A new study led by University College London (UCL) researchers suggests that halting axon degeneration triggered by glioblastoma could slow tumor progression while preserving neurological function. The findings, published in Nature, provide fresh insight into the biology of early-stage glioblastoma and open potential therapeutic avenues by linking neurodegeneration research with cancer biology. Tumor–brain interactions in early disease Glioblast…