Biological Effects of Rapid Short Pulses of Focused Ultrasound for Drug Delivery to the Brain
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Biological Effects of Rapid Short Pulses of Focused Ultrasound for Drug Delivery to the Brain
Abstract Focused ultrasound in combination with intravenously injected microbubbles offers a non-invasive and localised method to deliver drugs across the blood-brain barrier, enabling targeted treatment of brain disorders. Recently, we have shown that applying sequences of Rapid Short-Pulses (RaSP; 5 μs pulses emitted at 1.25 kHz grouped into 10 ms bursts) of ultrasound can deliver drugs with an improved efficacy and safety profile compared wit…
·Charlottesville, United States
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