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NFL Betting Promos: Get Best Chargers-Chiefs Odds, Apps, Sportsbook Offers

The NFL's second consecutive Week 1 game in Brazil features strong defenses, with Chiefs favored by 3 points and simulations showing a 50% chance Chargers cover the spread.

  • On Friday, the Kansas City Chiefs and Los Angeles Chargers open the season in São Paulo at Neo Química Arena, kickoff at 8 p.m. ET, with the Chiefs favored by 3 points and a 46.5 total set.
  • Kansas City Chiefs arrive looking to rebound from a Super Bowl loss after a 15-2 season, while Los Angeles Chargers, under Jim Harbaugh, shift identity following an 11-6 campaign.
  • Defenses again shape expectations, with both units top-six in scoring defense last year, as the Chargers allowed 18.5 and the Chiefs 20.5 points, while Isiah Pacheco's over 45.5 rushing yards prop highlights his key role.
  • The game's result will give the winner a head start in the AFC West race, with an expert recommending Chargers +3 and a half-unit moneyline play amid a prediction favoring Chargers 27, Chiefs 24.
  • Given the teams don't meet again until Week 15, Friday's result influences future scheduling matchups, while Missouri sports-betting launch on Dec. 1 will allow Chiefs fans to place prop bets like Will Dissly over 1.5 receptions.
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Sports Illustrated broke the news in New York, United States on Friday, September 5, 2025.
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