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Autoimmune Disease Curbed in Mice by FcγRI-Blocking Antibodies
The high-affinity Fc gamma receptor I (FcγRI) plays a crucial role in the immune system. Also known as CD64, FcγRI is a high-affinity receptor on myeloid cells that bind to the Fc region of IgG antibodies and trigger cellular functions such as phagocytosis and cytokine production. In a normal immune response, FcγRI is activated by immune complexes—clusters of antibodies bound to pathogens, which mark them for clearance. However, overactivation o…
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1 Articles
Autoimmune Disease Curbed in Mice by FcγRI-Blocking Antibodies
The high-affinity Fc gamma receptor I (FcγRI) plays a crucial role in the immune system. Also known as CD64, FcγRI is a high-affinity receptor on myeloid cells that bind to the Fc region of IgG antibodies and trigger cellular functions such as phagocytosis and cytokine production. In a normal immune response, FcγRI is activated by immune complexes—clusters of antibodies bound to pathogens, which mark them for clearance. However, overactivation o…
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