US EditionAn End to Anaphylaxis? Old Drug Shows New Potential
UNITED STATES, AUG 7 – FDA-approved asthma drug zileuton blocked a key gut pathway and prevented severe allergic reactions in 95% of mice, prompting early-stage human clinical trials to assess effectiveness.
- On August 7, 2025, two new studies published in Science journal revealed a key step in food-induced anaphylaxis involving genetic factors and leukotrienes.
- Food allergies affect more than 33 million in the U.S., but only two FDA-approved treatments exist, highlighting a significant treatment gap.
- Revealing leukotriene D4's role in allergen transport, LTD4 promotes allergen crossing the gut epithelium, which studies suggest could trigger anaphylaxis in mice.
- Dr. Adam Williams's team reported that Zileuton reversed mice’s risk from 95% susceptible to 95% protected in early trials.
- Millions living with food allergies could benefit from a simple pill, as Jorge Emiliano Gómez Medellín predicts Zileuton might offer protection if human trials prove effective.
17 Articles
17 Articles
An end to anaphylaxis? Old drug shows new potential
One in 10 people live with the fear of accidental exposures to things like peanuts, eggs or milk. An EpiPen is always at their side. Now, a Chicago research team says a drug already on the market could put an end to severe reactions — and save lives. Kirshenbaum family’s 9-year-old Micah has a severe food allergy. “Every meal we go to we have to think about it,” her father Eric Kirshenbaum said. “We’ve had three scares where we’ve had to epi her…
Asthma drug blocks food-induced anaphylaxis in mice
Credit: MasterPhoto-DK (CC BY 2.0 https://creativecommons.org/licenses/by/2.0/deed.en) Two teams of scientists have prevented anaphylaxis in mice with an US FDA-approved asthma drug. The drug, Zileuton, temporarily shields allergic mice from allergens they have ingested by blocking a newly discovered anaphylactic pathway in the gut before it activates. The first study, published in the journal Science, revealed that mice naturally resistant to o…
NewScientist
Anti-Aging, Acupuncture and Health NewsCommon asthma drug could prevent life-threatening allergic reactions
A single dose of the asthma medication zileuton stopped severe allergic reactions in mice by blocking food allergens from entering the bloodstream
This Already-Approved Drug Could Stop Food Allergies' Worst Reactions
A pair of new papers unlock crucial new insights into what goes on in the body when anaphylaxis occurs, and indicate how an existing asthma medication could one day help prevent these life-threatening allergic reactions
Asthma drug Zileuton prevents severe food allergy reactions in mouse study
A drug already FDA-approved for asthma was found to nearly eliminate life-threatening allergic reactions to food allergens in mice—a breakthrough that could lead to new protection for millions of people living with food allergies, reports a new Northwestern Medicine study.
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