US EditionAntibiotics instead of images: Generative AI designs molecules that kill drug-resistant bacteria
Penn researchers developed AMP-Diffusion AI, generating 50,000 antimicrobial peptides, with two matching FDA-approved drugs' effectiveness in animal skin infection tests, showing no adverse effects.
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Of the 46 major candidates, two were shown to be able to reduce skin infections in rats, with an effect on the level of medicines already used for this purpose.
Generative AI creates life-saving antibiotics from scratch
What if generative AI could design life-saving antibiotics, not just art and text? In a new Cell Biomaterials paper, Penn researchers introduce AMP-Diffusion, a generative AI tool used to create tens of thousands of new antimicrobial peptides (AMPs) - short strings of amino acids, the building blocks of proteins - with bacteria-killing potential.
Generative AI designs new antibiotic peptides
Credit: Jackie Niam/Getty Images Artificial intelligence is already capable of sifting through huge amounts of data to identify promising new antibiotics in existing compounds. Now, researchers have shown that generative AI models can invent antimicrobial peptides (AMPs) from scratch. “We’re leveraging the same AI algorithms that generate images, but augmenting them to design potent new molecules,” says Professor Pranam Chatterjee of Pennsylvani…
Antibiotics instead of images: Generative AI designs molecules that kill drug-resistant bacteria
What if generative AI could design life-saving antibiotics, not just art and text? In a new Cell Biomaterials paper, Penn researchers introduce AMP-Diffusion, a generative AI tool used to create tens of thousands of new antimicrobial peptides (AMPs)—short strings of amino acids, the building blocks of proteins—with bacteria-killing potential. In animal models, the most potent AMPs performed as well as FDA-approved drugs, without detectable adver…
AI Designs Thousands of Peptides with Antibiotic Potential
Artificial intelligence (AI) has been able to design tens of thousands of candidate antimicrobial peptides (AMPs), some of which can perform as well as standard antibiotics. The findings, in Cell Biomaterials, demonstrate the capacity of generative AI—which forms the basis of ChatGPT—to design antibiotics as yet undiscovered naturally through evolution. Using the generative AI platform AMP-diffusion, researchers were able to create amino-acid se…
The generater artificial intelligence tool, AMP-Diffusion, analyzes large groups of synthetic antimicrobial molecules (substances that kill bacteria) and proposes applications for new antibiotics, medicines used to kill or prevent the multiplication of bacteria. Scientists found that, in rats with skin infection, the most effective compounds with IA produced a comparable performance to those approved by Food and Drug Administration (FDA) and did…
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