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Analysis Finds Aerobic Exercise to Be Most Effective for Reducing Depression and Anxiety

A meta-meta-analysis of nearly 80,000 participants finds supervised aerobic exercise matches or exceeds benefits of therapy and antidepressants for depression and anxiety.

  • A review combining dozens of prior meta-analyses led by Neil Richard Munro, published in the British Journal of Sports Medicine in 2026, found exercise reduces depression and anxiety, with supervised aerobic programs showing the strongest benefits.
  • Faced with inconsistent earlier results, the team undertook a meta-meta-analysis because hundreds of studies and dozens of prior meta-analyses produced mixed results, using advanced statistical techniques and excluding people with chronic physical diseases.
  • The analysis shows distinct prescriptions: for depression, effect size −0.61 improved most with more than 24 weeks, moderate intensity, and three or more days weekly, while anxiety improved with up to eight weeks, lower intensity, and once or twice weekly.
  • Clinicians should consider prescribing exercise and refer patients to aerobic fitness classes or supervised walking/running programs, with specific 'prescriptions' detailing type, intensity, duration, and frequency, despite barriers like underuse and lack of training.
  • Despite the findings, researchers caution that low AMSTAR-2 quality ratings, English-language publications, publication bias in anxiety studies, and patient barriers could limit scaling supervised programs.
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Depression and anxiety affect up to 1 in 4 people worldwide, with a higher prevalence among young people and women. A new analysis shows that aerobic exercise, such as running, swimming, or dancing, can be more effective in alleviating their symptoms.

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MedPage Today broke the news in New York, United States on Tuesday, February 10, 2026.
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