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Amy Schumer Shares She Lost 50 Pounds “to Survive” After Cushing Syndrome Diagnosis

Amy Schumer lost 50 pounds to survive Cushing syndrome, a condition causing dangerous facial puffiness, with her diagnosis confirmed in February 2024, she said on Instagram.

  • On Dec. 2, Amy Schumer clarified she lost 50 pounds, not 30, in an Instagram post and a Reel filmed at home on Monday, December 1 by her son Gene.
  • Her disclosure links the transformation to a 2024 Cushing syndrome diagnosis, which Amy Schumer said caused extreme facial puffiness and can be life-threatening if untreated, according to the Mayo Clinic and National Institutes of Health.
  • Schumer said she has used Mounjaro and had prior medication experiences, acknowledging past plastic surgery and that Ozempic caused a 30-pound loss but left her bedridden.
  • Photos of Amy Schumer without a wedding ring fueled split rumors, which she and People framed as normal marital issues the couple is privately addressing, unrelated to her weight loss or Chris Fischer's autism.
  • Schumer offered to explain more about her perimenopause and health, saying she's open to questions and has used Mounjaro and hormone prescriptions via Midi Health this past year.
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In February 2024, Amy Schumer spoke of her remarkable physical change, especially in her face.The actress responded to comments with an ironic Instagram post explaining that there were some "medical and hormonal things going on," but that she was fine.Shortly afterwards, in an interview published in News Not Noise by Jessica Yellen, Schumer revealed that she suffers from exogenous Cushing syndrome, caused by receiving steroid injections that gen…

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US Magazine broke the news in United States on Tuesday, December 2, 2025.
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