US EditionAlzheimer’s fighting infusion delivered in Canada for the first time
The neuroprotective compound P7C3-A20 restored NAD+ levels in two Alzheimer’s mouse models, reversing brain damage and cognitive decline according to Case Western Reserve University researchers.
- Case Western Reserve University researchers reported P7C3-A20 restored cognition and reversed brain damage in mouse models of advanced Alzheimer’s.
- Researchers focused on NAD+ because it is essential for cellular energy and declines with age, and human Alzheimer’s brain samples showed a 30% reduction in NAD+, indicating disrupted NAD+ homeostasis.
- P7C3-A20 crosses the blood–brain barrier and prevents excessive NAD+ breakdown via the salvage pathway, producing biological improvements including lowered phosphorylated tau 217 and restored barrier integrity.
- Despite promising mouse results, the team cautions these do not guarantee human success; the researchers say the next step is well-controlled human clinical trials to determine safety and efficacy while laboratory follow-ups will pinpoint brain energy balance aspects and test complementary treatments.
- Concerns about NAD+ supplements make this salvage-pathway approach notable, as it may reduce risks linked to over-the-counter NAD+ supplements; experts say the findings challenge Alzheimer's irreversibility.
6 Articles
6 Articles
healthcaretoday.news
South Florida ReporterExperimental treatment restores memory in mice - Health Care Today
For many years, scientists have considered Alzheimer’s disease to be irreversible. For this reason, much research has focused on preventing or slowing disease progression, rather than reversal. However, a recent study in mice investigated a compound with neuroprotective properties that may repair damage and recover cognitive function. In the animal models of advanced Alzheimer’s disease, the compound could restore levels of a vital cellular ener…
A new study reveals that a compound, P7C3-A20, could reverse the advanced cognitive decline associated with Alzheimer's disease. By restoring the energy balance of the brain via the NAD+ molecule, this treatment allowed, on animal models, to repair brain functions without removing the amyloid plaques, opening a promising path towards recovery.
Coverage Details
Bias Distribution
- 67% of the sources are Center
Factuality
To view factuality data please Upgrade to Premium
