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Early Menopause Hormone Therapy Linked to Alzheimer's Prevention

Starting hormone replacement therapy within five years of menopause reduces Alzheimer's risk by up to 32%, while beginning at 65 or later raises the risk by 38%, researchers found.

  • Researchers presented a meta-analysis showing hormone replacement therapy timing affects Alzheimer's risk among menopausal women at the American Neurological Association meeting.
  • The analysis combined data from over 50 studies and revealed that initiating hormone replacement treatment shortly after menopause reduces the risk of Alzheimer's, whereas beginning the therapy at age 65 or later is associated with an increased risk.
  • Hormone therapy eases symptoms from estrogen decline like hot flashes and may support heart and bone health, but its protective brain effects depend on early use.
  • Dr. Vaibhav explained that beginning hormone replacement therapy soon after menopause might help protect the brain, but once cognitive decline or Alzheimer's has begun, such treatment is unlikely to slow the progression of these conditions.
  • The findings remain preliminary and suggest women discuss hormone therapy early with doctors, but the evidence is insufficient to recommend it for Alzheimer's prevention.
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Hormone Therapy Timing Key to Alzheimer's Prevention

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Timing Of Menopause Hormone Therapy Key To Protecting Brain From Alzheimer's

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psychiatrictimes.com broke the news in on Tuesday, September 16, 2025.
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