US EditionGut bacteria linked to fertility issues in women with polycystic ovary syndrome, research indicates
UNITED KINGDOM, JUN 30 – Study finds women with PCOS have 39% more isoleucine and 50% less Parabacteroides merdae, linked to doubled risk of pregnancy complications, researchers say.
- A study presented on June 30, 2025, at the 41st ESHRE meeting revealed that women with PCOS have distinct gut bacteria and metabolic patterns linked to early uterine aging and pregnancy risks.
- The study followed 220 women under 35 across 44 Chinese cities, including 110 with PCOS who had nearly twice the risk of pregnancy complications despite similar pregnancy rates.
- Researchers found lower levels of the gut bacterium Parabacteroides merdae and higher branched-chain amino acid isoleucine, which may impair uterine health and increase cellular aging.
- Dr. Liu noted that the results reveal premature signs of uterine aging, and researchers suggest that monitoring P. merdae levels and branched-chain amino acids may help identify high-risk PCOS patients and tailor individualized treatments.
- Although no specific PCOS treatments target the microbiome yet, scientists suggest probiotics or diet changes could improve outcomes, marking a step toward personalized reproductive care.
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12 Articles
Gut bacteria and amino acid imbalance linked to higher miscarriage risk in women with PCOS
A study presented at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that women with polycystic ovary syndrome (PCOS) have distinct gut microbiota and metabolic signatures linked to premature endometrial aging and a higher risk of adverse pregnancy outcomes.
Gut microbiota and metabolic changes linked to pregnancy risks in women with PCOS
A new study presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that women with polycystic ovary syndrome (PCOS) have distinct gut microbiota and metabolic signatures linked to premature endometrial aging and a higher risk of adverse pregnancy outcomes.
Gut bacteria linked to fertility issues in women with polycystic ovary syndrome, research indicates
PCOS is the most common hormonal condition in women of reproductive age and yet, despite being a leading cause of infertility, very little is known about what causes it or how to treat it.
NewScientist
Anti-Aging, Acupuncture and Health NewsAltered gut microbiome linked to fertility issues in people with PCOS
People with PCOS who struggle to conceive tend to have lower levels of a gut microbe that has been linked to endometrial function
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How can PCOD affect the psychological health of young women? PCOD affects the psychological health of young women by causing mood swings, anxiety, and low self-esteem. Hormonal imbalances can lead to emotional distress and body image issues. Irregular periods and weight gain may increase stress. Many young women with PCOD feel frustrated or depressed, especially […] The post How does PCOD affect the mental health of young women? appeared first o…
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