US EditionGut bacteria linked to fertility issues in women with polycystic ovary syndrome, research indicates
- A study presented on June 30, 2025, at the 41st ESHRE meeting revealed that women with PCOS have distinct gut bacteria and metabolic patterns linked to early uterine aging and pregnancy risks.
- The study followed 220 women under 35 across 44 Chinese cities, including 110 with PCOS who had nearly twice the risk of pregnancy complications despite similar pregnancy rates.
- Researchers found lower levels of the gut bacterium Parabacteroides merdae and higher branched-chain amino acid isoleucine, which may impair uterine health and increase cellular aging.
- Dr. Liu noted that the results reveal premature signs of uterine aging, and researchers suggest that monitoring P. merdae levels and branched-chain amino acids may help identify high-risk PCOS patients and tailor individualized treatments.
- Although no specific PCOS treatments target the microbiome yet, scientists suggest probiotics or diet changes could improve outcomes, marking a step toward personalized reproductive care.
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Gut microbiota and metabolic changes linked to pregnancy risks in women with PCOS
A new study presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that women with polycystic ovary syndrome (PCOS) have distinct gut microbiota and metabolic signatures linked to premature endometrial aging and a higher risk of adverse pregnancy outcomes.
Gut bacteria linked to fertility issues in women with polycystic ovary syndrome, research indicates
PCOS is the most common hormonal condition in women of reproductive age and yet, despite being a leading cause of infertility, very little is known about what causes it or how to treat it.
NewScientist
Anti-Aging, Acupuncture and Health NewsAltered gut microbiome linked to fertility issues in people with PCOS
People with PCOS who struggle to conceive tend to have lower levels of a gut microbe that has been linked to endometrial function
Microbiota Vault Initiative Update Given on World Microbiome Day
Last Friday, June 27, was World Microbiome Day. The theme was “Microbiome 101: What You Need to Know” with the overall goal of “simplifying the science, focusing on raising awareness, and providing clear, accessible information about microbiomes.” An announcement was coordinated with the day that marks a significant step forward in the global effort to create a “microbial Noah’s Ark” to preserve the world’s diverse collection of healthy microbes…
Altered gut microbiome linked to fertility issues in people with PCOS - Los Angeles Weekly Times
Restoring levels of specific gut microbes might help treat fertility issues in people with PCOS Science Photo Library / Alamy Stock Photo Women with polycystic ovary syndrome (PCOS) have lower levels of a gut microbe, which appears to raise the risk of pregnancy complications. PCOS is the most common hormonal condition in women of reproductive age and is a leading cause of infertility. Yet relatively little is understood about what causes it or …
Gut Microbiota Alterations Associated with Fertility Challenges in PCOS Patients
Restoring the levels of specific intestinal microorganisms may help treat fertility problems in people with PCOS Science Photo Library / Alamy Stock Photo Women diagnosed with polycystic ovarian syndrome (PCOS) seem to face a heightened risk of pregnancy complications linked to lower levels of gut microorganisms. PCOS stands as the most prevalent hormonal disorder among [...] The post Gut Microbiota Alterations Associated with Fertility Challeng…
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