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Alcohol and the Brain Interact Through Immune Cells, New Research Shows

Summary by Medical Xpress
A Cleveland Clinic research team studying alcohol and the brain discovered a new way that alcohol abuse can cause brain dysfunction and damage: through immune cells called microglia. The research also identified a potential new treatment target.

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Research results have been published showing that microglia cause brain dysfunction by destroying the extracellular matrix that supports neurons upon alcohol exposure. A research team at the Cleveland Clinic in the United States demonstrated that blocking MyD88, a specific protein pathway in immune cells, can prevent drowsiness and reduced motor performance that occur after excessive drinking.

Dr. Dimitrios Davalos and his research team at the Cleveland Clinic discovered how alcohol abuse activates brain immune cells, which destroy the structure that supports neurons.A new mechanism through which alcohol abuse can cause dysfunction and damage to the brain has been identified by a Cleveland Clinic research team with lead Greek, focusing on cells of the immune system called microglia. The study also highlighted a potential new target fo…

Scientists have determined how excessive alcohol use damages the brain. According to the study, alcohol changes the activity of cells of the immune system called microglia, directing them to break down the structure that supports nervous tissue.

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Neuroscience News broke the news in The Woodlands, United States on Tuesday, October 13, 2026.
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