US EditionScientists Reverse Parkinson’s Symptoms in Mice — Could Humans Be Next?
- Researchers led by Professor Kay Double at the University of Sydney treated Parkinson-like mice with a copper supplement for three months to test motor improvement.
- The team built on their 2017 discovery that abnormal SOD1 protein accumulates in Parkinson's brains, causing damage and contributing to disease progression.
- In the study, mice receiving the copper treatment showed significantly better motor function while placebo mice experienced symptom decline, confirming the treatment's effect.
- Professor Double reported that all treated mice experienced significant enhancements in their movement abilities, indicating potential for this approach to benefit individuals with Parkinson’s disease as well.
- The researchers plan clinical trials targeting faulty SOD1 protein as a potential therapy to slow Parkinson's progression, indicating hope for future human treatments.
21 Articles
21 Articles
Parkinson's disease: How the affected side shapes the disease's course
Parkinson's disease affects approximately 10 million people worldwide. It typically begins asymmetrically, initially impacting only one side of the body. Although it first manifests through motor symptoms—such as tremors, slowed movement, or muscle rigidity—it also leads to cognitive impairments, anxiety, and depression, aspects of the disease whose progression remains poorly understood.
The Independent
The Independent (US)Scientists find subtle new early signs of Parkinson’s
Behaviours like rearing, walking, and hunching were found tied to loss of neurons associated with Parkinson’s
A better understanding of these disorders would allow for faster intervention at the best time.
Scientists Reverse Parkinson’s Symptoms in Mice: ‘We were astonished by the success’
Groundbreaking research by the University of Sydney has identified a new brain protein involved in the development of Parkinson’s disease and a way to modify it, paving the way for future treatments for the disease. With the aim of finding new treatments to slow or stop its progression, the research team has spent more than […] The post Scientists Reverse Parkinson’s Symptoms in Mice: ‘We were astonished by the success’ appeared first on Good Ne…
Scientists reverse Parkinson’s symptoms in mice — Could humans be next?
Scientists at the University of Sydney have uncovered a malfunctioning version of the SOD1 protein that clumps inside brain cells and fuels Parkinson’s disease. In mouse models, restoring the protein’s function with a targeted copper supplement dramatically rescued movement, hinting at a future therapy that could slow or halt the disease in people.
Parkinson’s disease tremor explained by reflex loop changes
Many Parkinson’s Disease tremor behaviors that were considered hard to interpret can be explained by control systems modeling of mid-level motor control. The model in this paper includes stretch reflex loop with feedback delay and tonically controlled antagonist muscles. It also includes Basal Ganglia circuit that commands (schedules) gain changes in the reflex feedback loop. Computational analysis of the control systems model shows how the gain…
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