US EditionA 'Suicide' Gene Therapy Shows Efficacy Against Ewing Sarcoma in Preclinical Models
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A team from the Institute for Rare Disease Research (IIER) of the Carlos III Health Institute (ISCIII) has developed a gene therapy that has demonstrated the ability to destroy Ewing tumor cells in preclinical models through 'suicidal' genes.
Spanish researchers have used for the study an adenovirus, a virus frequently used in gene therapy against cancer, to introduce into Ewing sarcoma cells a ‘suicide’ gene derived from the herpes simplex virus (HSV-TK). This work takes prominence on Wednesday, September 24, World Cancer Research Day. This name refers to the use of a gene whose expression causes the ‘suicide’ of the cells themselves that express it, favoring the elimination of tumo…
A study published in the journal Scientific Reports by a team from the Carlos III Institute of Health (ISCIII) has shown in preclinical studies that it is possible to destroy the tumor cells of Ewing’s sarcoma by using a strategy based on ‘suicidal’ genes. This name refers to the use of a gene whose expression causes the ‘suicide’ of the cells themselves that express it, favoring the elimination of tumor cells. The work is led by a group from th…
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