Evolutionary Mutation Weakens Human Immune Response to Solid Tumors

Persistent mutation burden drives sustained anti-tumor immune responses

Tumor mutation burden is an imperfect proxy of tumor foreignness and has therefore failed to consistently demonstrate clinical utility in predicting responses in the context of immunotherapy. We evaluated mutations in regions of the genome that are unlikely to undergo loss in a pan-cancer analysis across 31 tumor types (n = 9,242) and eight immunotherapy-treated cohorts of patients with non-small-cell lung cancer, melanoma, mesothelioma, and hea…

Evolutionary mutation weakens human immune response to solid tumors

New research from UC Davis Comprehensive Cancer Center has uncovered an evolutionary change that may explain why certain immune cells in humans are less effective at fighting solid tumors compared to non-human primates.

A single genetic mutation may have made humans more vulnerable to cancer than chimpanzees

New research from UC Davis Comprehensive Cancer Center has uncovered an evolutionary change that may explain why certain immune cells in humans are less effective at fighting solid tumors compared to non-human primates. This insight could lead to more powerful cancer treatments.

UC Davis Study Uncovers Genetic Mutation Affecting Immunotherapy Response in Solid Tumors

A recent study conducted by scientists at UC Davis has identified a genetic mutation that could be responsible for making solid tumors unresponsive to immunotherapy. Published in the Nature Communications journal, the research initially aimed to understand why non-human primates exhibit a lower incidence of certain cancers compared to humans. The findings not only shed light on this discrepancy but also have significant implications for the futu…

Gene change weakens human immunity against solid tumours, study finds - Connected to India News I Singapore l UAE l UK l USA l NRI

Scientists in the United States have found a small change in human genes that may explain why people are more likely to get certain types of cancer compared to other primates. This discovery may help in creating better treatments, especially for solid tumours that are hard to treat with current methods. Representational image. Photo Courtesy: Pixabay Researchers from the University of California, Davis studied a protein called Fas Ligand, which …

Small Genetic Change in Humans Weakens Immune Attack on Solid Tumors

New research from UC Davis Comprehensive Cancer Center has uncovered an evolutionary change that may explain why certain immune cells in humans are less effective at fighting solid tumors compared to non-human primates.