A single enzyme keeps neuroblastoma alive—how to shut it off

A single enzyme keeps neuroblastoma alive—how to shut it off

The tumor begins before birth. Somewhere in the developing fetus, neural crest cells that should have matured into adrenal tissue or sympathetic ganglia take a wrong turn, and a child is born harboring a malignancy that may not declare itself for months. Neuroblastoma accounts for roughly 28% of all cancers diagnosed in infants across Europe and the United States. In its gentlest form, it regresses on its own, a fire that puts itself out. In its…

Scientists Discover How to Disable Key Enzyme That Sustains Neuroblastoma

JERUSALEM, ISRAEL — Neuroblastoma, a cancer rooted deep in the earliest moments of human development, continues to confound clinicians and researchers alike. This malignancy originates when neural crest cells in the developing fetus deviate from their intended path, forming tumors that can remain undetected for months after birth. Representing approximately 28 percent of all infant […]