A new view of intestinal regeneration: What fetal reversion could mean for IBD and cancer

A new view of intestinal regeneration: What fetal reversion could mean for IBD and cancer

Dynamic switching between revival stem cells and conventional intestinal stem cells enables efficient tissue repair without exhausting the stem cell pool, report researchers from Institute of Science Tokyo. Using organoid and mouse disease models, the researchers uncovered how flexible stress-tolerant cell states contribute to intestinal repair—providing a better understanding of the biological mechanisms driving intestinal regeneration.