A common immunosuppressant may alter brain immune cells during early development

A common immunosuppressant may alter brain immune cells during early development

Researchers at University of Tsukuba have discovered that an immunosuppressive drug affects microglia, the resident immune cells of the brain. In mouse models, the drug reduced levels of guanosine nucleotides, which are essential for cell signaling and morphology. This reduction weakened the activity of small G proteins, leading to changes in microglial shape and function. The findings are published in the journal Molecular Brain.