US EditionThe Nobel Prize in medicine goes to 3 scientists for work on peripheral immune tolerance
- The Nobel Prize for 2025 in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their discoveries concerning peripheral immune tolerance, as announced by the Royal Swedish Academy of Sciences on October 6, 2025.
- The laureates identified regulatory T cells that prevent immune cells from attacking the body, improving understanding of autoimmune diseases, according to Olle Kämpe, chair of the Nobel Committee.
- Shimon Sakaguchi discovered a new class of immune cells in 1995, revealing a more complex immune system, and linked this knowledge to the Foxp3 gene, which governs the development of regulatory T cells.
- The award ceremony will occur on December 10, 2025, honoring those who have contributed significantly to humanity, as noted by Olle Kämpe, chair of the Nobel Committee.
199 Articles
199 Articles
U.S.–Japanese Trio Win Medicine Nobel for Immune System Research
Mary E. Brunkow and Fred Ramsdell of the United States and Japan’s Shimon Sakaguchi won the Nobel Prize in Medicine on Monday, October 6th, for research into how the immune system is kept in check, the Nobel jury said. Their discoveries have been decisive for understanding how the immune system functions and why we do not all develop serious autoimmune diseases. The three were honoured “for their discoveries concerning peripheral immune toleranc…
On Monday, the Karolinska Institute in Stockholm, Sweden, awarded the Nobel Prize in Physiology or Medicine to American scientists Mary Brunkow and Fred Ramsdell, and Japanese Shimon Sakaguchi “for their discoveries about peripheral immune tolerance.” The winners identified the “immune system safety guards,” regulatory T cells, which prevent the immune system from attacking our own body, as the committee explained.
The Nobel Prize in Medicine 2025 was awarded to researchers who identified "guardians of the immune system" as regulatory T cells.
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