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Makary Resigns as FDA Commissioner

The departure follows weeks of pressure over drug reviews, flavored vaping products and mifepristone, while six people led the FDA drug center in a year.

  • On Tuesday, FDA Commissioner Marty Makary stepped down after 13 months leading the agency, with Kyle Diamantas expected to serve as acting commissioner following a decision by Health and Human Services Secretary Robert F. Kennedy Jr. and White House approval.
  • Makary's tenure faced months of internal turmoil marked by sweeping layoffs, turnover among senior leadership, and repeated clashes with lawmakers and the pharmaceutical industry over his handling of mifepristone and flavored vapes.
  • Last Tuesday, the FDA authorized fruit-flavored vapes fulfilling a 2024 campaign promise, while the Supreme Court recently allowed nationwide mifepristone access despite Republicans continuing to push for reversals of telehealth dispensing rules.
  • This departure marks the administration's fourth high-profile exit this year, following Labor Secretary Lori Chavez DeRemer's April resignation and the removal since January of Homeland Security Secretary Kristi Noem and Attorney General Pam Bondi.
  • Regulatory uncertainty now surrounds the FDA's enforcement priorities, as the agency has not released its review of abortion pills—a process Makary reportedly asked officials to delay until after the midterms.
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FDA chief exits after clashing with pharma, vaping, and anti-abortion groups

At the FDA, Makary failed to win the staff's confidence after mass layoffs, leadership changes and a series of controversies.

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KERO broke the news on Tuesday, May 12, 2026.
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