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New research reveals clues about memory from the brains of 'SuperAgers'

CHICAGO, ILLINOIS, AUG 8 – A 25-year Northwestern study of 290 SuperAgers shows their brains resist or tolerate Alzheimer’s pathology, with 77 brains autopsied revealing key neurobiological traits behind memory resilience.

  • Mesulam Center researchers published Thursday a 25-year review, revealing SuperAgers aged 80+ perform as well as much younger adults in memory.
  • More than 7 million Americans live with Alzheimer’s, projected to soar to nearly 13 million by 2050, according to the Alzheimer’s Association.
  • With advanced imaging, researchers found SuperAgers have three times fewer tau tangles in the hippocampus, a thicker anterior cingulate cortex, and microglia levels matching those of people in their 30s, 40s, and 50s.
  • Building on these discoveries, Dr. Sandra Weintraub, Professor at Northwestern University Feinberg School of Medicine, said `This opens the door to new interventions aimed at preserving brain health well into the later decades of life`.
  • Today, Gefen said her team’s most exciting findings stem from brains of SuperAgers who have died, involving 101 participants in Mesulam Center research.
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80-year-old ‘Superager’ brains operate like those of a 50-year old. Here’s why

Why does the brain of some people stay sharp into their 80s and beyond? An expert explains what 25 years of exploring the brain tissue of “SuperAgers” has discovered.

·Atlanta, United States
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Medical Xpress broke the news in on Thursday, August 7, 2025.
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