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ScienceRecent development of new immune checkpoint inhibitors has been particularly successfully in cancer treatment, but still the majority patients fail to benefit. Converting resistant tumors to immunotherapy sensitive will provide a significant improvement in patient outcome. Here we identify Mi-2β as a key melanoma-intrinsic effector regulating the adaptive anti-tumor immune response. Studies in genetically engineered mouse melanoma models indicat…See the Story
Mi-2β Promotes Immune Evasion in Melanoma by Activating EZH2 Methylation
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Science · Grand RapidsVan Andel Institute - Van Andel Institute transforms human health through groundbreaking biomedical research and cutting-edge science education.Read Article