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Wnt Signaling in Fibroblasts Drives Gastric Cancer Metastasis to the Liver
The study reveals that Wnt signaling in fibroblasts induces hyaluronan production, creating a metastatic niche in the liver that promotes gastric cancer spread, with hyaluronan degradation reducing metastasis.
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Wnt signaling in fibroblasts drives gastric cancer metastasis to the liver
Researchers at the Cancer Research Institute and the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have uncovered a critical mechanism that enables gastric cancer to spread to distant organs.
·United States
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Wnt signaling drives stomach cancer spread by reshaping surrounding tissue, finds study
Researchers at the Cancer Research Institute and the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have uncovered a critical mechanism that enables gastric cancer to spread to distant organs. Their study shows that cancer cells stimulate Wnt signaling in surrounding stromal fibroblasts to produce hyaluronan, creating a supportive microenvironment that promotes metastasis. These findings provide new insight into how metastatic t…
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