Why are patients with mitochondrial disease more susceptible to infections? New study finds the answer

Why are patients with mitochondrial disease more susceptible to infections? New study finds the answer

Patients with rare mitochondrial diseases already face a host of serious health issues, from muscle weakness to neurological problems and heart conditions. But one of their most life-threatening challenges has remained a mystery—why are they so vulnerable to severe infections?

Single-cell multi-omics resolved analysis of mitochondrial genome-wide mutational burden, constraint, and mosaicism

Mitochondria contain their own circular, multi-copy genome, encoding essential components of the mitochondrial respiratory chain vital for cellular metabolism. Mitochondrial DNA (mtDNA) mutations occur more frequently than nuclear mutations and are associated with various diseases. While single-c...

New JAX Study Reveals Why Patients with Mitochondrial Disease Are More

Patients suffering from rare mitochondrial diseases confront a myriad of severe health challenges, including muscle weakness, neurological impairments, and cardiac complications. Yet among these difficulties, a particularly puzzling and life-threatening issue has remained elusive: their heightened vulnerability to severe bacterial infections. Recent groundbreaking research from The Jackson Laboratory (JAX) is shedding light on this critical ques…