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Paving the Way for Early Esophageal Cancer Detection:

  • A study published in *The American Journal of Gastroenterology* found that WATS-3D, or wide-area transepithelial sampling with 3D computer-assisted analysis, increases the detection of Barrett's esophagus and dysplasia in patients with gastroesophageal reflux undergoing screening upper endoscopy.
  • Barrett's esophagus, a complication of chronic GERD and a precursor to esophageal adenocarcinoma, affects an estimated 3.3 million Americans, making early detection critical.
  • The study by Shaheen and colleagues, involving 23,933 consecutive patients, revealed that WATS-3D confirmed BE diagnosis in an additional 19.3% of patients compared to forceps biopsies alone and influenced clinical management in 90.7% of cases with positive WATS-3D but negative FB results.
  • According to Philip O. Katz, MD, director of the GI Function Laboratories at Weill Cornell Medicine, "WATS added to biopsy that has been traditionally done with the Seattle protocol increases the yield of intestinal metaplasia and likely dysplasia in patients being screened for Barrett's."
  • CDx Diagnostics announced on March 25, 2025, an alternative specimen acquisition technique developed by Dr. Sidney Olefson of Prima CARE, enhancing cellular adequacy and improving AI and pathologist analysis, potentially leading to earlier intervention and improved outcomes in the fight against esophageal cancer, where incidence has surged 600% in four decades.
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Medscape broke the news in United States on Tuesday, March 25, 2025.
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