Immune Cell Neighborhoods Control Cancer Spread and Metastasis Formation
The study found neutrophils help hybrid cancer cells spread, while removing them in mice cut lung metastases and reduced these cells.
4 Articles
4 Articles
Bad neighbors: How immune cells help cancer cells get ready to spread
Most cancer deaths are not caused by the original tumor, but by metastases, which form when cancer cells leave the original tumor and spread to other organs. To do so, cancer cells must loosen their attachment to other cancer cells and become more mobile so they can move away from the tumor, a process called epithelial-to-mesenchymal transition, or EMT. EMT is a progressive phenomenon, and cancer cells go through an intermediate "hybrid" stage that is the best at forming metastases.
Experts have identified a key mechanism of metastases in cancer. Researchers from the Université libre de Bruxelles (ULB) have discovered that...
Certain immune cells communicate with cancer cells to promote the formation of metastases, researchers from the ULB discovered.
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