Researchers Identify Key Pathway that Drives T-Cell Exhaustion in Cancer Immunotherapy

Researchers identify key pathway that drives T-cell exhaustion in cancer immunotherapy

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center used a CRISPR screen to identify a key molecular pathway that drives exhaustion in cancer-fighting immune cells, limiting their ability to keep tumors under control.

Scientists Discover a Molecular Switch That Drives T-Cell Exhaustion in

UCLA researchers used a genome-wide CRISPR screen to identify the Cullin-5 RING E3 ligase complex as a key driver of T-cell exhaustion, and blocking this pathway helped engineered immune cells stay active longer and fight solid tumors more effectively in preclinical models.

Novel Molecular Pathway Identified to Combat T-Cell Exhaustion in Cancer Resea...

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center used a CRISPR screen to identify a key molecular pathway that drives exhaustion in cancer-fighting immune cells, limiting their ability to keep tumors under control.

UCLA Researchers Identify Key Pathway That Drives T-Cell Exhaustion in Cancer Immunotherapy

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center used a CRISPR screen to identify a key molecular pathway that drives exhaustion in cancer-fighting immune cells, limiting their ability to keep tumors under control.