Tumor Transcriptional Activity Predicts Chemotherapy Response in TNBC

Tumor Transcriptional Activity Predicts Chemotherapy Response in TNBC

Researchers at The University of Texas MD Anderson Cancer Center have shown that a novel metric, tumor-specific total mRNA expression (TmS), better predicts chemotherapy response than existing methods for defining triple-negative breast cancer (TNBC) subtypes. The new, pathway-independent tool, developed by Wenyi Wang, PhD, professor of bioinformatics and computational biology, and colleagues, is derived from matched RNA and DNA sequencing data.…