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Three drugs eliminate microscopic brain metastases before detectable tumors form in mice

Summary by Medical Xpress
Metastasis, the process by which a tumor spreads throughout the body, is associated with the majority of cancer deaths. The Brain Metastasis Group at the Spanish National Cancer Research Centre (CNIO) has investigated the earliest stages in which metastatic cells establish themselves in distant organs and discovered a transient phase during which these metastatic seeds are particularly vulnerable.

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Center

They have discovered an opportunity to remove 'seeds' from brain metastases when it is in a very incipient phase.

·Madrid, Spain
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Center

A team of brain cancer researchers, led by Manuel Valiente, has discovered that cancer cells are paused when they nest in a new organ and have managed to destroy them in mice and human samples.

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Researchers at the National Center for Oncological Research of Spain (CNIO) have shown that they can eliminate brain metastases through three drugs, two of which are already authorized for other indications. More information: A vaccine stops relapses of colon and pancreas cancer with the most common mutation

·Spain
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The process by which a tumor spreads to other organs, known as metastases, is responsible for the vast majority of cancer deaths and, therefore, the Achilles heel of oncology researchers. This week, however, hopeful news arrives from the Brain Metastasis Group of the National Center for Oncological Research (CNIO), which has discovered a vulnerability in this “armature” of the tumor. This is an unknown phase in which tumor cells, after colonizin…

·Madrid, Spain
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La Vanguardia broke the news in Barcelona, Spain on Monday, September 28, 2026.
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