Targeted Phages Curb Crohn's-Linked Gut Inflammation by Disabling Harmful E. Coli Traits
The phages reduced inflammation in lab and stool-sample tests and may help identify Crohn’s patients most likely to benefit.
9 Articles
9 Articles
Mcmaster researchers develop targeted phage therapy for inflammatory bowel disease
A research team at McMaster University has developed a targeted approach to treating inflammatory bowel disease (IBD) using bacteriophages, viruses that infect specific bacteria, to disarm harmful microbes without disrupting the broader gut ecosystem.
Targeted phages curb Crohn's-linked gut inflammation by disabling harmful E. coli traits
A research team at McMaster University has developed a targeted approach to treating inflammatory bowel disease (IBD) using bacteriophages, viruses that infect specific bacteria, to disarm harmful microbes without disrupting the broader gut ecosystem.
International researchers take a big step towards addressing this increasingly common pathology
When patients with Crohn’s disease or ulcerative colitis suffer from an inflammatory outbreak, doctors frequently turn to antibiotics to try to stop the bacteria that trigger the pathology. The problem is that these drugs act as a cluster bomb: they destroy both harmful microbes and beneficial bacteria, further aggravating the imbalance of intestinal flora and leaving long-term sequelae. Now, an innovative international study seems to have found…
Viruses that render problematic intestinal bacteria harmless could support the treatment of inflammatory intestinal disease, a study in mice shows.
Crohn’s Disease Phage Therapy Neutralizes Inflammatory E. coli in Mouse Model
By taking advantage of the microbe-targeting capabilities of bacteriophages (phages), researchers at McMaster university have devised a supportive therapy for Crohn’s disease that disarms a type of E. coli bacteria that drives inflammation in the gut without disrupting the broader gut microbiome. The team showed that the phage therapy also improved responses to low doses of a conventional corticosteroid in a mouse model of Crohn’s disease, sugge…
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