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The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy
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The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy
In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism underlying the ULK complex assembly have yet to be fully clarified. Here, we predicted the core interactions organizing the ULK complex using AlphaFold, which proposed that the intrinsically disordered region of ATG13 engages the bases of the two UBL domains i…
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