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The influence of drug loading on dissolution behaviours and stability of surfactant-containing amorphous solid dispersions
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The influence of drug loading on dissolution behaviours and stability of surfactant-containing amorphous solid dispersions
Abstract This study explores the impact of drug loading (DL) on the physical stability, dissolution performance, and micellisation behaviour of binary and ternary amorphous solid dispersions (ASDs) of lumefantrine (LUM), a poorly soluble antimalarial drug. Based on preliminary evaluations, Soluplus® was chosen as the polymer for its excellent solubility enhancement and amorphous stabilisation of LUM, while Kolliphor® RH40 was employed as a surfa…
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