US EditionMapping Inhibitory Sites on the RNA Polymerase of the 1918 Pandemic Influenza Virus Using Nanobodies
5 Articles
5 Articles
Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies
Influenza A viruses cause seasonal epidemics and global pandemics, representing a considerable burden to healthcare systems. Central to the replication cycle of influenza viruses is the viral RNA-dependent RNA polymerase which transcribes and replicates the viral RNA genome. The polymerase undergoes conformational rearrangements and interacts with viral and host proteins to perform these functions. Here we determine the structure of the 1918 inf…
A historical study revealed key mutations in the 1918 virus, which allowed for rapid adaptation and resistance. How these findings could be key to an upcoming international health emergency
Researchers from the universities of Basel and Zurich were able to determine for the first time the virus genome of the flu pandemic from 1918-1920 in Switzerland using a historical preparation from the medical collection of UZH. According to the genetic information, this virus shows already at the beginning of the world's most lethal diseases.
Scientists from the universities of Basel and Zurich have decrypted the viral genome of the 1918-1920 influenza pandemic in Switzerland using a historical specimen. According to the study, this virus presented key adaptations to the human being from the beginning of the most deadly influenza pandemic in the world.
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