Chemotherapy-Based Conditioning Matches Outcomes of Total Body Irradiation for MRD-Negative B-ALL

TBI-Free Conditioning Before Transplant Effective in MRD-Negative B-ALL

(MedPage Today) -- ORLANDO -- A conditioning regimen free from total body irradiation (TBI) appeared to be just as effective as standard of care (SoC) in a common type of childhood leukemia, according to a phase II study. The EndRad trial evaluated...

Chemotherapy-based conditioning matches outcomes of total body irradiation for MRD-negative B-ALL

In a new trial, patients with B-acute lymphoblastic leukemia (B-ALL) who had no evidence of remaining cancer cells after prior treatment, experienced comparable outcomes whether they received chemotherapy-based conditioning or total body irradiation (TBI), the standard conditioning regimen used before hematopoietic cell transplantation.

‘Practice-changing’ findings may spare some young patients with leukemia from radiation

ORLANDO — Some younger patients with B-cell acute lymphoblastic leukemia may be able to avoid total body irradiation conditioning prior to allogeneic hematopoietic stem cell transplantation, according to study results.Children, adolescents and young adults who were deemed minimal residual disease (MRD) negative by next-generation sequencing prior to transplant and received non-total body

Removal of Total Body Irradiation Does Not Alter Efficacy in B-ALL

The primary end point of EFS was met in patients given conditioning without TBI, along with allogeneic HCT in a subset of patients with B-ALL.

TBI-Free Transplant Works for Younger Patients with B-ALL | Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways

Targeted Oncology connects oncology professionals with updates on immunotherapy, biomarkers, cancer pathways, and targeted precision medicine strategies.

Pediatric and AYA B-ALL Treatment Effective Without Total Body Irradiation

For pediatric and young adult patients with B-cell acute lymphoblastic leukemia, removal of total body irradiation did not compromise efficacy.