Oral Menopausal Hormone Therapy Linked to Higher Blood Clot Risk; Transdermal Treatment Shows No Overall Increase
Researchers found oral menopausal hormone therapy raised clot risk, while skin patches did not, in a study of nearly 100,000 Danish women.
- On Wednesday, a large study published in The BMJ linked oral menopausal hormone therapy to increased risks of blood clots, stroke, and heart attack among nearly 100,000 Danish women ages 50 to 69.
- Unlike oral forms, transdermal therapy showed no general increased thrombotic risk because it avoids the liver stimulation that increases clotting factors and promotes blood clot formation.
- Data shows oral therapy carried an absolute increased rate of 0.09% for venous thromboembolism per year, with high-dose oral estradiol above 1 mg per day linked to stroke and heart attack risks.
- Prof Robert Storey of the University of Sheffield noted results confirm transdermal patches carry lower risks, while co-author Amani Meaidi argued against a "single risk profile" for hormone therapy.
- Researchers acknowledged the observational study cannot prove cause and effect and may not apply to all ethnically diverse populations, though the FDA removed "black box" warnings last year.
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11 Articles
Study finds oral hormone replacement therapy increases venous thromboembolism risk
Current use of oral menopausal hormone therapy (commonly known as hormone replacement therapy or HRT) is associated with an increased risk of blood clots in legs / lungs regardless of dose or treatment duration, finds a large Danish study published by The BMJ today.
Oral Hormone Therapy Linked to Blood Clots Regardless of Treatment Dose or Duration: Study
Oral menopausal hormone therapy is associated with a higher risk of blood clots in the legs or lungs, regardless of dose or treatment duration, according to a large Danish study published in The BMJ. ...
Oral menopausal hormone therapy linked to higher blood clot risk; transdermal treatment shows no overall increase
Current use of oral menopausal hormone therapy (commonly known as hormone replacement therapy or HRT) is associated with an increased risk of blood clots in the legs or lungs regardless of dose or treatment duration, finds a large Danish study published by The BMJ.
Menopausal Hormone Therapy Thrombotic Risk Varies by Dose, Route of Administration
(MedPage Today) -- While taking oral menopausal hormone therapy, women faced increased thrombotic risks that varied by the method of use, dosage, and duration of treatment, a nationwide study from Denmark showed. Venous thromboembolic risk remained...
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