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Syphilis Making a Comeback, Health Officials Warn. CDC Map Shows Where Risk Is Highest

  • In January 2026, the U.S. Centers for Disease Control and Prevention reported that maternal syphilis rates rose 28% from 2022 to 2024, climbing from over 280 to nearly 360 cases per 100,000 births.
  • COVID-19 pandemic disruptions limited screening and treatment services, while 2026 appropriations recommend cutting $70 million from combined HIV, STI and tuberculosis programs, exacerbating existing healthcare access barriers.
  • Barriers to healthcare access affect 1 in 4 pregnant people who lack prenatal care access in their first trimester, while screening rates for those with private insurance range from 80% to 90% during pregnancy.
  • Congenital syphilis can cause miscarriage, stillbirth, or long-term developmental delays in infants; unfortunately, the long-acting penicillin injection required for treatment remains in short supply.
  • Universal screening at three points—first trimester, third trimester, and delivery—offers the most effective prevention method for congenital syphilis; alternatively, patients may consider doxycycline PEP within 72 hours of exposure.
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  • 73% of the sources are Center
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The Conversation broke the news on Friday, May 1, 2026.
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