Study links methylglyoxal stress to immunotherapy resistance in triple-negative cancer

Study links methylglyoxal stress to immunotherapy resistance in triple-negative cancer

The metabolism of cancer cells may play a key role in their ability to evade the immune system. This is demonstrated by a new study conducted by researchers at the University of Liège, which reveals how methylglyoxal stress – a by-product of tumor metabolism – promotes immunosuppression and the formation of metastases, and may contribute to resistance to immunotherapy and the progression of triple-negative cancer.

Triple-negative breast cancer: Tumor metabolite aids cancer's escape from immune system

Cancer cell metabolism may play a key role in tumors' ability to evade the immune system. In a study published in the Journal for ImmunoTherapy of Cancer, researchers from GIGA demonstrate that methylglyoxal, a byproduct of tumor metabolism, contributes to the creation of an environment that favors the progression of triple-negative breast cancer and resistance to immunotherapy.