US EditionStudy: Gut Hormone Could Potentially Accelerate Fat Burning
FGF19 hormone boosts sympathetic nervous system and adipose thermogenesis, enhancing fat burning, energy use, and blood glucose control in obese mice, study shows.
- Earlier this year the study published in the American Journal of Physiology- Endocrinology and Metabolism shows FGF19 signals the hypothalamus to raise sympathetic activity and adipose thermogenesis, increasing energy expenditure and promoting weight loss in obese mice.
- Amid a global obesity crisis noted by the World Atlas of Obesity 2025, over 1 billion people worldwide live with obesity, while FGF19 is mainly produced in the small intestine and regulates metabolism in the liver.
- Administering FGF19 directly into mice brains revealed researchers randomized obese mice at eight weeks to regular or high-fat diets and found suppressing the sympathetic nervous system blocked hormone effects.
- The team says the finding could guide drugs that mimic FGF19, which reduced inflammation, improved cold tolerance, and stimulated thermogenic adipocytes in obese mice.
- Earlier this year the team began follow‑up studies to explore how to raise natural FGF19 production and its effects on hypothalamic inflammation and eating‑behavior pathways, supported by Sāo Paulo Research Foundation .
11 Articles
11 Articles
The Next Ozempic? Scientists Discover Gut Hormone That Tells Brain to Burn Fat
An experiment at the State University of Campinas found that FGF19, a substance produced in the intestine, acts on specific brain regions to trigger energy burning and heat production, paving the way for the development of new drugs. Recent research on mice has uncovered how a hormone produced in the intestine communicates with the brain [...]
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fapesp.brResearch reveals how hormone accelerates fat burning and promotes weight loss in obese mice
An experiment conducted at the State University of Campinas showed that FGF19, produced in the intestine, acts on specific regions of the brain, causing the body to burn energy to produce heat; the discovery paves the way for new drugs.
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Intestinal hormone accelerates fat burning and promotes weight loss in obese mice
Research carried out on mice has revealed how a hormone released by the intestine acts on the brain and helps regulate the body's energy expenditure. FGF19 (fibroblast growth factor 19) activates mechanisms that stimulate the use of more energy, burn fat, and favor weight control and blood glucose levels in obese animals.
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