US EditionStudy: COVID mRNA Vaccines Boost Cancer Survival
Patients with advanced lung or skin cancer receiving immunotherapy who got COVID-19 mRNA vaccines showed median survival nearly doubling from 20.6 to 37.3 months, study finds.
- On Wednesday, researchers reported in journal Nature that advanced lung and skin cancer patients receiving Pfizer or Moderna shots within 100 days of immune checkpoint inhibitors lived substantially longer.
- The team explains that mRNA vaccines act like an alarm triggering T-cells and lymph nodes to recognize and kill tumour cells, potentially sensitising immune-resistant tumours to checkpoint inhibitors.
- Detailed figures show the analysis used records of nearly 1,000 patients including 884 advanced lung cancer patients, 180 vaccinated lung cancer patients, and 210 metastatic melanoma patients, with survival rising from 26.7 months to up to 40 months.
- Researchers are preparing randomized clinical trials, including a nationwide clinical trial in lung cancer due to start before the end of the year, to test adding mRNA vaccines to standard care for millions of patients.
- Because the analysis was retrospective, the study is not randomized and confounding could explain results; follow-up faces skepticism and funding pressures after Health Secretary Robert F. Kennedy Jr. cut $500 million.
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Could COVID mRNA Vaccines Boost Effectiveness of Cancer Immunotherapy?
Key Takeaways
Vaccination with mRNA vaccines awakens the immune system to better fight cancer, new research shows.
New study shows mRNA coronavirus vaccines prolonged lives of some cancer patients
A new study suggests mRNA coronavirus vaccines effectively prolonged the lives of certain cancer patients.The study, published Wednesday in the journal Nature, examined health records of patients who received the vaccine within 100 days of starting immunotherapy for lung and skin cancer.The researchers at the University of Florida and the University of Texas MD Anderson Cancer Center believe the vaccines awakened the body's immune system to the …
How COVID mRNA vaccines may make cancer treatments more effective
Researchers found that COVID-19 mRNA vaccines, when given within 100 days of starting immune checkpoint inhibitors, were linked to significantly longer survival in lung and melanoma cancer patients. The vaccines trigger a powerful type-I interferon response that primes tumors to become more responsive to immunotherapy.
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